Protein has a high termic effect; it may increase satiety and prevent muscle waste during weight loss. A large European multicenter study shows how moderate increase in daily protein intake, circa 20 grams per day, together with low glycemic choices may keep the weight off most effectively after an initial weight loss. However, study leaves many questions open and failed to demonstrate satiety increase during high protein diet. Larsen T et al. N Eng J Med 2010; 363: 2102-2113