According to the recent data, intake of saturated fat (SFA) is not independent risk factor for coronary heart disease. A replacement of SFA in diet with polyunsaturated fats may decrease the incidence of coronary heart disease. Less is known about the effect of saturated fat intake on incidence of strokes. In this Japanese prospective cohort intake of saturated fat was linked to fewer strokes. The following presentation gives the details and discusses the relevance of the findings. Yamagishi K et al. Am J Clin Nutr 2010;92:759-765.